ANTISENSE OLIGODEOXYRIBONUCLEOTIDE Meaning and
Definition
-
An antisense oligodeoxyribonucleotide (ASO) is a short synthetic strand of DNA or RNA that is produced to specifically bind to a target messenger RNA (mRNA) molecule. It is referred to as "antisense" because its nucleotide sequence is complementary to a specific portion of the target mRNA molecule. This means that the ASO can base-pair with the mRNA and form a stable complex, leading to a decrease in the amount of functional mRNA available for translation into protein.
ASOs are designed to selectively inhibit the expression of specific genes or modify their activity by interfering with the protein translation process. By binding to the target mRNA, ASOs can physically obstruct the ribosome's ability to read the mRNA code accurately or induce its degradation, resulting in reduced protein production. This mechanism of gene expression regulation provides a potential therapeutic approach for various diseases that are caused by abnormal protein levels or functionality.
The development of ASOs has attracted significant attention in the field of molecular biology and pharmaceutical research due to their potential therapeutic applications. Their ability to selectively modulate gene expression has shown promise in treating genetic diseases, neurodegenerative disorders, viral infections, and certain types of cancers. Additionally, ASOs can also serve as valuable research tools to study gene function and validate potential drug targets.
In summary, antisense oligodeoxyribonucleotides are short synthetic DNA or RNA molecules that can selectively bind to target mRNA molecules, interfering with the protein translation process and modulating gene expression.
Common Misspellings for ANTISENSE OLIGODEOXYRIBONUCLEOTIDE
- zntisense oligodeoxyribonucleotide
- sntisense oligodeoxyribonucleotide
- wntisense oligodeoxyribonucleotide
- qntisense oligodeoxyribonucleotide
- abtisense oligodeoxyribonucleotide
- amtisense oligodeoxyribonucleotide
- ajtisense oligodeoxyribonucleotide
- ahtisense oligodeoxyribonucleotide
- anrisense oligodeoxyribonucleotide
- anfisense oligodeoxyribonucleotide
- angisense oligodeoxyribonucleotide
- anyisense oligodeoxyribonucleotide
- an6isense oligodeoxyribonucleotide
- an5isense oligodeoxyribonucleotide
- antusense oligodeoxyribonucleotide
- antjsense oligodeoxyribonucleotide
- antksense oligodeoxyribonucleotide
- antosense oligodeoxyribonucleotide
- ant9sense oligodeoxyribonucleotide
- ant8sense oligodeoxyribonucleotide
Etymology of ANTISENSE OLIGODEOXYRIBONUCLEOTIDE
The word "antisense" in "Antisense Oligodeoxyribonucleotide" comes from the Latin prefix "anti", which means "against", and the English noun "sense", which refers to "the meaning conveyed by language". In molecular biology, antisense refers to a nucleotide sequence that is complementary to a specific messenger RNA (mRNA) sequence.
"Oligodeoxyribonucleotide" is composed of several components. "Oligo" comes from the Greek word "oligos", meaning "few" or "little". "Deoxyribonucleotide" combines "deoxyribose", which is a sugar molecule present in DNA, and "nucleotide", which refers to the building blocks of DNA and RNA.
Infographic
Add the infographic to your website:
