How Do You Spell CYSTATHIONINE SYNTHETASE?

1. Cystathionine synthetase is an enzyme that plays a crucial role in the metabolic pathway of cysteine biosynthesis. It is responsible for catalyzing the condensation of serine and homocysteine, resulting in the formation of cystathionine. This enzyme is an essential component of the transsulfuration pathway, which is responsible for converting homocysteine to cysteine through a series of enzymatic reactions.

   Cystathionine synthetase is primarily found in the liver, but it is also present in other tissues such as the kidneys, brain, and intestines. It is a pyridoxal phosphate (PLP)-dependent enzyme, meaning it requires vitamin B6 as a cofactor for its activity. In addition to its role in cysteine biosynthesis, cystathionine synthetase also contributes to the production of hydrogen sulfide, a gas with important physiological functions in various tissues.

   Deficiencies or mutations in the cystathionine synthetase enzyme can lead to a metabolic disorder known as cystathionine beta-synthase deficiency or homocystinuria. This condition results in the accumulation of homocysteine and other toxic metabolites in the body, leading to various symptoms such as intellectual disability, skeletal abnormalities, cardiovascular problems, and eye abnormalities.

   Overall, cystathionine synthetase is an essential enzyme involved in the production of cysteine, an important sulfur-containing amino acid. Its function is critical in maintaining proper sulfur metabolism and preventing the accumulation of toxic metabolites in the body.

Common Misspellings for CYSTATHIONINE SYNTHETASE

The word "cystathionine synthetase" can be broken down into its components: "cystathionine" and "synthetase".

1. Cystathionine: The term "cystathionine" is derived from the Greek "kystis" (meaning bladder) and "thion" (sulfur) combined with the suffix "-ine" indicating a substance related to or derived from. Cystathionine is an amino acid found in proteins.

2. Synthetase: "Synthetase" is a term derived from the Greek "syn" (together) and "tithenai" (to place). It refers to an enzyme that catalyzes the synthesis or formation of a specific substance.