Dicesium salt methotrexate is a chemical compound that is used primarily as a cytotoxic and immunosuppressant drug in the treatment of cancer and autoimmune diseases. It belongs to the class of medications called antifolates and acts by inhibiting the enzyme dihydrofolate reductase, which is essential for the synthesis of DNA, RNA, and proteins in cells.
The term "dicesium salt" refers to the form in which methotrexate is prepared for therapeutic use. It is a compound derived from cesium, a soft and silvery-white metal, and consists of two cesium cations (Cs+) combined with the methotrexate molecule. The cesium ions enhance the stability and solubility of methotrexate, allowing for more efficient drug delivery and absorption in the body.
Methotrexate, in its dicesium salt form, is typically administered as an injectable solution or in oral tablet form. It is commonly prescribed in the treatment of various types of cancers, such as breast cancer, lung cancer, leukemia, and lymphoma, as well as autoimmune diseases like rheumatoid arthritis and psoriasis.
As a powerful cytotoxic drug, dicesium salt methotrexate works by stopping the growth and division of rapidly multiplying cells. This action is particularly important in the treatment of cancer, as cancer cells tend to replicate and spread more rapidly than normal cells. By inhibiting their ability to reproduce, methotrexate helps to slow down or halt the progression of the disease.
However, the use of dicesium salt methotrexate can also be associated with side effects, including nausea, vomiting, mouth sores, hair loss, liver toxicity, and bone marrow suppression. Close monitoring and dosage adjustments
