GERM CENTRE Meaning and
Definition
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A germ centre is a specialized region found in secondary lymphoid organs, particularly in lymph nodes and white pulp areas of the spleen. It serves as a site where the immune response is initiated and where B cells undergo the process of somatic hypermutation and affinity maturation.
The germ centre is characterized by its distinct structure and cellular composition. Within the germ centre, B cells divide rapidly and undergo genetic mutations in their immunoglobulin genes, leading to the generation of a diverse repertoire of antibodies. These mutated B cells, known as germinal center B cells, compete for antigen binding and selection by T cells and follicular dendritic cells.
Additionally, the germ centre consists of follicular dendritic cells, T cells, and antigen-presenting cells, which provide crucial support and signaling for the germinal center reaction. The region is also rich in follicular helper T cells, which provide essential signals for B cell survival, proliferation, and differentiation.
Overall, the germ centre is a dynamic microenvironment that orchestrates the complex processes of B cell activation, affinity maturation, and antibody production. It plays a pivotal role in the adaptive immune response by ensuring the generation of high-affinity antibodies that can effectively recognize and neutralize invading pathogens or antigens.
Common Misspellings for GERM CENTRE
- ferm centre
- verm centre
- berm centre
- herm centre
- yerm centre
- term centre
- gwrm centre
- gsrm centre
- gdrm centre
- grrm centre
- g4rm centre
- g3rm centre
- geem centre
- gedm centre
- gefm centre
- getm centre
- ge5m centre
- ge4m centre
- gern centre
- gerk centre
Etymology of GERM CENTRE
The word "germ" comes from the Latin word "germen", meaning "sprout" or "bud". "Centre" is derived from the Latin word "centrum", meaning "middle" or "center". Therefore, "germ centre" refers to the central or core part where germination or growth occurs. However, it is important to note that the term "germ centre" is more commonly used in the context of lymphoid tissues, specifically referring to specialized areas where the activation and maturation of B cells take place.
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