GYRA PROTEIN Meaning and
Definition
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GyrA protein refers to a type II topoisomerase enzyme that is found in bacteria and plays a crucial role in maintaining the structure and stability of bacterial DNA. It belongs to the DNA gyrase family of proteins and is primarily involved in the process of DNA supercoiling and relaxation.
The gyrA protein functions by introducing transient breaks in the DNA strand and controlling the degree of supercoiling, which is necessary for DNA replication, transcription, recombination, and repair. This enzyme is primarily responsible for alleviating excessive torsional strain caused by the twisting and winding of the DNA helix during these processes.
The gyrA protein consists of two subunits, referred to as A and B. The A subunit possesses the active site responsible for DNA cleavage and rejoining, whereas the B subunit aids in binding to DNA and conferring specificity. The interaction between these subunits is vital for the overall functionality of the enzyme.
GyrA proteins are significant targets in the development of antibiotics since they play a crucial role in bacterial viability and proliferation. Inhibitors that specifically target the gyrA protein have been developed to disrupt the normal functioning of DNA gyrase, leading to DNA damage and cell death in bacteria.
Understanding the structure and mechanism of gyrA proteins has provided valuable insights into the development of antibiotics and the treatment of bacterial infections. Studying the gyrA protein has contributed to the broader field of molecular biology and has led to advancements in our understanding of DNA dynamics and its regulation in prokaryotic systems.
Common Misspellings for GYRA PROTEIN
- fyra protein
- vyra protein
- byra protein
- hyra protein
- yyra protein
- tyra protein
- gtra protein
- ggra protein
- ghra protein
- gura protein
- g7ra protein
- g6ra protein
- gyea protein
- gyda protein
- gyta protein
- gy5a protein
- gy4a protein
- gyrz protein
- gyrs protein
- gyrw protein
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