How Do You Spell HEREDITARY AUTOSOMAL DOMINANT SPASTIC PARAPLEGIA?

Pronunciation: [hɪɹˈɛdɪtəɹi ˌɔːtə͡ʊsˈə͡ʊmə͡l dˈɒmɪnənt spˈastɪk pˌaɹəplˈiːd͡ʒə] (IPA)

Hereditary Autosomal Dominant Spastic Paraplegia (HADSP) is a genetic disorder that affects the nervous system. The words "Hereditary," "Autosomal," and "Dominant" suggest that the condition is inherited and is caused by a single gene that dominates over any other gene. "Spastic" describes the muscle stiffness and spasms that are common symptoms, and "Paraplegia" refers to the paralysis of the lower limbs. The phonetic transcription of this word is /hɛrɪˈdɪtəri ɔːtəʊˈsəʊməl dɒmɪnənt ˈspæstɪk ˌpærəˈpliːdʒə/.

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HEREDITARY AUTOSOMAL DOMINANT SPASTIC PARAPLEGIA Meaning and Definition

  1. Hereditary Autosomal Dominant Spastic Paraplegia (HSP) is a genetic neurological disorder characterized by progressive weakness and stiffness (spasticity) of the lower limbs. It is inherited in an autosomal dominant pattern, meaning that an affected individual has a 50% chance of passing on the condition to each of their children.

    The main symptom of HSP is spastic paraplegia, which refers to the gradual onset and progressive worsening of muscle weakness and stiffness in the legs. This results in difficulty walking, a spastic gait, and an increased risk of falling. As the condition progresses, individuals may also experience muscle wasting (atrophy) and the loss of muscle control in the lower limbs.

    HSP is a heterogeneous disorder, meaning that there are numerous genetic changes or mutations that can cause the condition. These mutations generally affect the function of neurons in the corticospinal tracts, which are the nerve fibers that extend from the cerebral cortex to the spinal cord. The exact mechanism by which these mutations lead to the characteristic symptoms of HSP is not yet fully understood.

    Currently, there is no cure for HSP, and treatment primarily focuses on managing the symptoms and improving overall quality of life. This may involve physical and occupational therapy, assistive devices like braces or walkers, and medications to alleviate spasticity and muscle stiffness.

    In summary, Hereditary Autosomal Dominant Spastic Paraplegia is a genetic disorder characterized by progressive weakness, stiffness, and muscle wasting in the lower limbs. It is inherited in an autosomal dominant pattern and currently has no cure.

Common Misspellings for HEREDITARY AUTOSOMAL DOMINANT SPASTIC PARAPLEGIA

  • gereditary autosomal dominant spastic paraplegia
  • bereditary autosomal dominant spastic paraplegia
  • nereditary autosomal dominant spastic paraplegia
  • jereditary autosomal dominant spastic paraplegia
  • uereditary autosomal dominant spastic paraplegia
  • yereditary autosomal dominant spastic paraplegia
  • hwreditary autosomal dominant spastic paraplegia
  • hsreditary autosomal dominant spastic paraplegia
  • hdreditary autosomal dominant spastic paraplegia
  • hrreditary autosomal dominant spastic paraplegia
  • h4reditary autosomal dominant spastic paraplegia
  • h3reditary autosomal dominant spastic paraplegia
  • heeeditary autosomal dominant spastic paraplegia
  • hededitary autosomal dominant spastic paraplegia
  • hefeditary autosomal dominant spastic paraplegia
  • heteditary autosomal dominant spastic paraplegia
  • he5editary autosomal dominant spastic paraplegia
  • he4editary autosomal dominant spastic paraplegia
  • herwditary autosomal dominant spastic paraplegia
  • hersditary autosomal dominant spastic paraplegia

Similar spelling words for HEREDITARY AUTOSOMAL DOMINANT SPASTIC PARAPLEGIA