PYRIDOXINE KINASE Meaning and
Definition
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Pyridoxine kinase is an enzyme that plays a vital role in the metabolism of vitamin B6, specifically pyridoxine (also known as vitamin B6 or pyridoxol). This enzyme is responsible for the phosphorylation of pyridoxine, converting it into its active form, pyridoxal 5'-phosphate (PLP). Pyridoxal 5'-phosphate is a cofactor essential for the proper functioning of numerous enzymatic reactions involved in amino acid metabolism, neurotransmitter synthesis, and the synthesis and breakdown of glycogen.
Pyridoxine kinase acts by transferring a phosphate group from ATP (adenosine triphosphate) to pyridoxine, leading to the formation of PLP. This process is a crucial step in the activation of vitamin B6, as PLP is the primary biologically active form required for the majority of vitamin B6-dependent enzymatic reactions.
Deficiencies or mutations in the pyridoxine kinase gene can lead to impaired vitamin B6 metabolism, resulting in a condition known as pyridoxine-dependent epilepsy. Individuals with this condition require higher doses of vitamin B6 supplementation to maintain optimal health and prevent seizures.
Overall, pyridoxine kinase is an essential enzyme involved in the activation of pyridoxine to its active form, pyridoxal 5'-phosphate, which is necessary for a wide range of biochemical processes in the human body.
Common Misspellings for PYRIDOXINE KINASE
- oyridoxine kinase
- lyridoxine kinase
- -yridoxine kinase
- 0yridoxine kinase
- ptridoxine kinase
- pgridoxine kinase
- phridoxine kinase
- puridoxine kinase
- p7ridoxine kinase
- p6ridoxine kinase
- pyeidoxine kinase
- pydidoxine kinase
- pyfidoxine kinase
- pytidoxine kinase
- py5idoxine kinase
- py4idoxine kinase
- pyrudoxine kinase
- pyrjdoxine kinase
- pyrkdoxine kinase
- pyrodoxine kinase
Etymology of PYRIDOXINE KINASE
The word "Pyridoxine" originates from the Greek words "pyridine" and "oxus", which mean "fire" and "acid" respectively. Pyridoxine is a name given to vitamin B6 due to its pyridine ring structure.
On the other hand, "kinase" is derived from the Greek word "kinēsis", which means "movement". Kinases are enzymes that facilitate the transfer of phosphate groups from ATP molecules to other proteins or molecules, thus promoting different cellular processes.
Therefore, the term "Pyridoxine Kinase" refers to an enzyme that is responsible for phosphorylating or adding a phosphate group to pyridoxine, thereby activating and converting it into its active form as vitamin B6.
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