PYROGLUTAMATE AMINOPEPTIDASE Meaning and
Definition
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Pyroglutamate aminopeptidase, also known as pGAP, is an enzyme that plays a crucial role in various biological processes. It belongs to the family of aminopeptidases, which are enzymes responsible for removing the N-terminal amino acid residue from peptides and proteins.
The primary function of pyroglutamate aminopeptidase is to specifically cleave pyroglutamate (also known as pyroglutamic acid or pGlu) residues from the N-terminus of peptides. Pyroglutamate is a cyclized form of glutamic acid that is commonly found at the N-terminus of peptides and proteins. The removal of this pyroglutamate residue is essential for the activation, degradation, or modification of peptides involved in various physiological processes.
Pyroglutamate aminopeptidase acts by hydrolyzing the peptide bond between the pyroglutamate residue and the adjacent amino acid. This enzymatic activity liberates the pyroglutamate moiety from the peptide chain, allowing for further processing or degradation of the peptide.
The enzyme is widely distributed in various tissues and cells, including the brain, kidney, liver, and digestive system. It is involved in several physiological processes such as neurotransmission, metabolism, and protein catabolism. Dysregulation or dysfunction of pyroglutamate aminopeptidase has been associated with certain pathological conditions, including neurodegenerative disorders and cancer.
In summary, pyroglutamate aminopeptidase is an enzyme that specifically cleaves pyroglutamate residues from the N-terminus of peptides and proteins, facilitating their activation, degradation, or modification in various biological processes.
Common Misspellings for PYROGLUTAMATE AMINOPEPTIDASE
- oyroglutamate aminopeptidase
- lyroglutamate aminopeptidase
- -yroglutamate aminopeptidase
- 0yroglutamate aminopeptidase
- ptroglutamate aminopeptidase
- pgroglutamate aminopeptidase
- phroglutamate aminopeptidase
- puroglutamate aminopeptidase
- p7roglutamate aminopeptidase
- p6roglutamate aminopeptidase
- pyeoglutamate aminopeptidase
- pydoglutamate aminopeptidase
- pyfoglutamate aminopeptidase
- pytoglutamate aminopeptidase
- py5oglutamate aminopeptidase
- py4oglutamate aminopeptidase
- pyriglutamate aminopeptidase
- pyrkglutamate aminopeptidase
- pyrlglutamate aminopeptidase
- pyrpglutamate aminopeptidase
Etymology of PYROGLUTAMATE AMINOPEPTIDASE
The word "Pyroglutamate Aminopeptidase" comes from the combination of three parts: "pyroglutamate", "amino", and "peptidase".
1. Pyroglutamate: The term "pyroglutamate" is derived from the Greek word "pyros", meaning "fire", and "glutamate", which is derived from "gluta-" meaning glue or sticky. It was named based on its sticky and viscous nature when heated, leading to the association with fire. In the context of the word "Pyroglutamate Aminopeptidase", it refers to an amino acid derivative known as pyroglutamic acid.
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