THIOLASE Meaning and
Definition
-
Thiolase is an enzyme that plays a crucial role in the breakdown and metabolism of fatty acids. Specifically, it is involved in a process called beta-oxidation, which occurs primarily in the mitochondria of cells.
The thiolase enzyme catalyzes the fourth step in the beta-oxidation pathway, which involves the cleavage of a two-carbon unit from a fatty acyl-CoA molecule. This process releases acetyl-CoA, which can be further metabolized to produce energy or used for various other cellular processes.
Thiolase achieves this reaction by utilizing a unique coenzyme called coenzyme A (CoA), which is attached to the fatty acyl group. The enzyme forms a thioester intermediate between the acyl group and CoA, which is subsequently cleaved to release acetyl-CoA. The liberated acetyl-CoA can enter the citric acid cycle to generate ATP, a crucial energy source for cellular functions.
Thiolase is an essential enzyme in organisms that rely on the metabolism of fatty acids for energy, such as mammals, insects, and certain microorganisms. It plays a vital role in maintaining energy balance, particularly during prolonged fasting or periods of intense physical activity. Additionally, thiolase also contributes to the synthesis of ketone bodies, molecules that serve as alternative energy sources when glucose availability is limited, such as during starvation or certain metabolic disorders.
Understanding the function of thiolase is relevant not only for elucidating metabolic processes and energy balance but also for developing targeted therapies for metabolic diseases related to fatty acid metabolism dysfunction.
Common Misspellings for THIOLASE
Etymology of THIOLASE
The word "thiolase" has its etymology rooted in the Greek language. It is derived from two Greek words: "thio" meaning "sulfur" and "lase" meaning "to break". The suffix "-ase" in biology commonly refers to enzymes. Therefore, the term "thiolase" specifically refers to an enzyme that breaks down or forms chemical compounds involving sulfur atoms.
Infographic
Add the infographic to your website:
