TRYPARSAMIDE Meaning and
Definition
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Tryparsamide is a chemical compound that is classified as an antiprotozoal agent, primarily used in the treatment of African trypanosomiasis, also known as sleeping sickness. It was one of the earliest medications introduced to combat this parasitic infection, which is caused by the protozoa Trypanosoma brucei.
This organic compound belongs to the arsenic derivative family and exhibits potent trypanocidal properties. Its mechanism of action involves being selectively taken up by the trypanosomes, accumulating in their glycosomes, and disrupting cellular functions. This leads to the inhibition of vital metabolic processes within the parasite, ultimately causing its death and subsequent clearance from the host's system.
Tryparsamide is typically administered through intravenous injection due to its poor oral bioavailability. It has been widely utilized for both early and advanced stages of sleeping sickness, with varying success rates depending on the stage of the disease and the strain of the parasite involved. Its effectiveness is attributed to its ability to cross the blood-brain barrier, ensuring it can target the central nervous system where the parasite often resides.
Though tryparsamide has historically been a crucial therapeutic option, its usage has decreased in recent years due to the development of other drugs with improved safety profiles and efficacy. Nonetheless, its role in the history of African trypanosomiasis treatment remains significant, highlighting its importance in eradicating this life-threatening infection.
Common Misspellings for TRYPARSAMIDE
- rryparsamide
- fryparsamide
- gryparsamide
- yryparsamide
- 6ryparsamide
- 5ryparsamide
- teyparsamide
- tdyparsamide
- tfyparsamide
- ttyparsamide
- t5yparsamide
- t4yparsamide
- trtparsamide
- trgparsamide
- trhparsamide
- truparsamide
- tr7parsamide
- tr6parsamide
- tryoarsamide
- trylarsamide
Etymology of TRYPARSAMIDE
The word "tryparsamide" is a compound word formed from two parts: "trypanosome" and "arsenamide".
"Trypanosome" derives from the Greek words "trypanon" meaning "borer" or "auger" and "soma" meaning "body". The term "trypanosome" was coined by Sir David Bruce in 1899 to describe a group of parasitic protozoa that infect animals and cause diseases such as sleeping sickness.
"Arsenamide" is a compound word made up of "arsen-" referring to arsenic, a chemical element, and "-amide" indicating a compound that contains a carbonyl group attached to a nitrogen atom. Arsenic compounds have been used historically for their medicinal properties, particularly in the treatment of parasitic infections.
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