Pronunciation: [jˈuːvəmˌɔːɹuːlˌɪn] (IPA) 
The word "Uvomorulin" is a molecular compound found in vertebrates. It is composed of two parts: "Uvomo" and "rulin". The first portion, "Uvomo", is derived from the Latin word "uva" meaning grape and the Greek word "mórion" meaning egg yolk. The second portion "rulin" refers to a protein that helps cells in the body stick together. The correct pronunciation is [ˌʌvəʊmɔːruːlɪn].
Uvomorulin, also known as E-cadherin or epithelial cadherin, is a transmembrane protein primarily found in the cells of epithelial tissues. It plays a critical role in cell adhesion, maintaining the structural integrity of the epithelial layer, and facilitating the formation of tight junctions between adjacent cells.
The term "uvomorulin" stems from its initial discovery in uveal melanoma cells, but it has since been found in various types of cells, including those in the skin, intestine, and lung. As a member of the cadherin superfamily, uvomorulin is involved in calcium-dependent cell-cell adhesion, which is crucial for tissue development, morphogenesis, and organization.
In addition to its adhesive properties, uvomorulin also participates in various signaling pathways associated with cell proliferation, differentiation, and apoptosis. It facilitates communication between neighboring cells and influences cellular behavior, contributing to processes like tissue homeostasis and wound healing.
Altered expression or function of uvomorulin has been linked to numerous pathological conditions, including cancer metastasis, tissue inflammation, and developmental disorders. Mutations in the gene encoding uvomorulin have been associated with certain inherited diseases characterized by impaired epithelial integrity.
Overall, uvomorulin is an essential component of cell adhesion and tissue formation. Its multifaceted functions make it a molecule of great interest for researchers studying epithelial biology, tissue engineering, and therapeutic approaches targeting cell-cell interactions.
The word "Uvomorulin" is derived from the combination of two terms: "Uvo" and "morulin".
1. "Uvo" refers to "uveous", which is related to the uvea. The uvea is the middle layer of the eye that consists of the iris, ciliary body, and choroid. It is responsible for supplying blood to the retina.
2. "Morulin" is derived from the Latin word "morula", which means "a little mulberry". In biology, "morula" refers to an early stage of embryonic development where a solid ball of cells is formed.
Therefore, "Uvomorulin" is a term that relates to a specific adhesion molecule found in the uvea (eye) during embryonic development. It represents a molecule involved in the binding or adhesion between cells in this particular context.
